Study of Hypertension in Spontaneous Hypertensive Rats by Sequencing the Genomic DNA of Alpha2B Receptors
نویسنده
چکیده
S pontaneous hypertensive rats (SHR) are a genetic model of hypertension that is widely accepted in medical research because of the features they share with idiopathic hypertension in humans. During the last four decades, many researchers have attempted to determine the aetiology of hypertension in SHR by comparing this family of hypertensive experimental animals with other types of hypertensive (Dahl salt-sensitive) or normotensive (Wistar-Kyoto, Dahl salt-resistant) rats. The results have clearly demonstrated differences between SHR and normotensive rats with regard to the probable pathophysiological mechanisms implicated in hypertension, with special emphasis on the sympathetic nervous system. Study of Hypertension in Spontaneous Hypertensive Rats by Sequencing the Genomic DNA of Alpha2B Receptors
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